α,β-Methyleneadenosine 5'-triphosphate (sodium sal

Special reminder: Our product is only used for scientific research!

Product Name:α,β-Methyleneadenosine 5'-triphosphate (sodium salt)343364-54-4
Specifications: mg, 5mg, 0mg
Item number: GOY-0Y6320

Cas No. 343364-54-4

Alias: α - β - methylene ATP

化学名 5'-[hydrogen P-[[hydroxy(phosphonooxy)phosphinyl]methyl]phosphonate] adenosine, trisodium salt

Molecular formula CH5N5O2P3 • 3Na

Molecular weight 57.2

Solubility 0 mg/ml in PBS (pH 7.2)
Storage conditions Store at -20 ° C

General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
Product Description:
α,β-Methyleneadenosine 5’-triphosphate (αβ-methylene ATP) is a phosphonic analog of ATP that is characterized by the replacement of the bridging oxygen atom between the α- and β-phosphate groups with methylene. It is an agonist of P2X purinoceptors P2X and P2X3 (EC50 = ~ &#8M) and is ~,000-fold less potent at P2X2, P2X receptors 4-7, and P2Y receptors. [][2][3][4] Persistent activation of purinoceptors results in desensitization, resulting in an antagonist-like effect of αβ-methylene ATP. [5] αβ-methylene ATP is used as a stable analog of ATP to study the interaction of ATP with kinases and other proteins. [6][7] It weakly binds and inhibits adenylate cyclase in a calcium-dependent manner (Ki= ~0.5 mM). [8][9]

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