Evaluation of the Efficacy of Anti Wrinkle Cosmetics (GB/T 39066-2020)

Evaluation of the Efficacy of Anti Wrinkle Cosmetics (GB/T 39066-2020)

Evaluation of the efficacy of anti wrinkle cosmetics (GB/T 39066-2020):The anti wrinkle market is undergoing a transformation from 'conceptual claims' to' scientific verification '. According to the "Report on the Development of China's Cosmetics Industry", the market size of anti wrinkle products will exceed 80 billion yuan in 2024, but only 37% of the products have passed home level efficacy verification. GB/T 39066-2020 "Evaluation Method for Anti Wrinkle Efficacy of Cosmetics", as the first national standard for anti wrinkle testing in China, establishes a quantitative standard for wrinkle improvement through a dual technical route of 3D imaging and biomechanics. Zhongke Testing has completed over 600 batches of product testing based on this standard. Among them, a certain international brand, Shi Huang Chun Eye Cream, has been tested for 8 weeks and found to reduce wrinkle depth by 23.7% and improve skin elasticity by 18.4%, successfully passing the registration with the Drug Administration.

Standard Core Testing System and Technical Principles

GB/T 39066-2020 constructs a three-dimensional evaluation model of 'micro profile+macro elasticity'. In terms of wrinkle quantification, optical coherence tomography (OCT) technology is used to measure the three major parameters of wrinkle depth, width, and area with an accuracy of 0.01mm. Clinical data shows that the baseline value of static wrinkles around the eyes in healthy adults is usually between 0.15-0.35mm, and qualified anti wrinkle products should have a depth reduction of ≥ 15% after 12 weeks. In the detection of a face cream containing 2% bose, the average depth of fishtail lines decreased from 0.28mm to 0.21mm, reaching a significant improvement standard.

Skin elasticity testing using German Cutometer ® MPA580. Obtain key parameters such as R2 (total elasticity) and R7 (biological elasticity) through the principle of negative pressure suction release. The standard stipulates that the R2 value increase after the use of anti wrinkle products should be ≥ 0.1. The R7 value increase should be ≥ 0.08. In the actual test, the essence containing hexapeptide-8 increased the R2 value of the subjects' faces from 0.32 to 0.41. The bioelasticity improved by 28.1%, which verified the anti wrinkle mechanism of neurotransmitter inhibitory components.

Standardized testing process and quality control

Subject screening must meet strict inclusion criteria: females aged 35-65, meeting Glogau wrinkle classification II-III (mild to moderate wrinkles), and have not used anti wrinkle products in the past 3 months. Each group has a sample size of ≥ 30 cases to ensure statistical significance. A clinical study conducted by a multinational corporation showed that when the sample size increased from 20 to 30, the confidence level of the test results increased from 85% to 95%.

The experimental design adopts a double-blind control principle and is divided into a blank control group, a matrix control group, and three dose groups. Use 2mg/cm ² of the test product daily for 12 consecutive weeks, with key time points of 4 weeks (short-term effect), 8 weeks (mid-term effect), and 12 weeks (long-term effect). Environmental control requirements include constant temperature (22 ± 1 ℃) and constant humidity (50 ± 5% RH). Participants need to sit quietly for 30 minutes before testing to avoid interference factors such as temperature and exercise.

The reliability of data is guaranteed through three-level quality control: daily instrument calibration (accuracy error ≤ 2%), two person parallel experiments (data deviation<5%), and third-party blind review. A laboratory comparison experiment showed that the difference in wrinkle area measurement among different operators for the same subject was only 3.2%, far below the standard allowed threshold of 10%.

Technological Innovation and Practical Application Cases

3D skin topology imaging technology breaks through the limitations of traditional 2D photography and achieves micro scale wrinkle reconstruction through the PRIMOS system. In the testing of a certain visual alcohol eye cream, a three-dimensional model showed that after 8 weeks of use, the volume of forehead wrinkles in the subjects decreased from 1.2mm ³ to 0.89mm ³, with a volume change rate of 25.8%, which was better than the 18.3% of flat images. This technology has become the 'golden evidence' claimed by high proof anti wrinkle products.

In vitro 3D skin model accelerated efficacy screening using EpiSkin ™ Recombinant epidermal model, observe collagen type IV expression through immunofluorescence staining. A certain plant extract increased collagen expression by 42% in model experiments, and subsequent human trials confirmed that it can improve skin firmness by 16.7%. This' in vitro in vivo 'dual validation mode shortens the product development cycle by 40%.

Advantages and Industry Value of Testing Services

The Zhongke Testing Anti Wrinkle Laboratory is equipped with a complete set of equipment certified by ISO 17025, including Vectra ® H1 3D imaging system (resolution 0.1mm), DUB ® Ultrasonic skin tomography scanner (22MHz high-frequency probe) can synchronously obtain deep indicators such as epidermal thickness and dermal density. The meat and vegetable products of a certain medical beauty brand have been confirmed through ultrasound testing to increase the thickness of the dermal mesh layer by 11%, providing direct evidence for the claim of 'dermal support'.

Compliance support covers the entire process: from formula pre evaluation (to avoid illegal additives), clinical trial design (ethical review) to report issuance (in compliance with the "Cosmetic Efficacy Claim Evaluation Specification"). In 2024, assisted a domestic brand in completing the testing of the 'Bose Einstein+Collagen Peptide' composite formula. The report showed that after 12 weeks, the skin elasticity parameter R7 increased by 0.12 and the wrinkle area decreased by 29%, successfully entering the Tmall anti wrinkle category

With the deepening implementation of the Regulations on the Supervision and Administration of Cosmetics, GB/T 39066-2020 has become the 'passport' for anti wrinkle products to enter the market. Enterprises should attach importance to early detection intervention and establish technological barriers in fierce competition through the scientific path of 'basic research → clinical verification → market claims'. According to data from Zhongke Testing, the anti wrinkle products that have been systematically validated have a 2.3-fold increase in consumer repurchase rate and a 65% decrease in complaint rate, truly achieving a win-win situation of commercial value and consumer trust.