Small animal nebulization drug dispenser

Small animal nebulization drug dispenser

At present, nebulization inhalation has become an important means of respiratory diseases, and the development of inhalation types has also been pushed to a new height. Accurate research and development of animal models and animalsDrug administration has become a bottleneck that hinders research and development. Although there are currently two types of medical nebulization devices available on the market for animal experiments: one is jet nebulization and the other is ultrasonic nebulization, both of these nebulization devices have their own insurmountable shortcomings. The pneumatic spray device is difficult to achieve consistency and degree due to the influence of multiple factors such as air pressure, air hole, air passage, etc. The problem with existing ultrasonic atomizers is the generation of high temperatures, which alter their activity (such as cortex and proteins) and limit their range of use. We have conducted intensive research on this and discovered an ultrasonic microporous atomization device that can overcome the shortcomings of the current two atomization devices. This device is different from previous ultrasonic atomizers in that it does not rely on ultrasonic vibration to form the "cavitation effect" of the liquid, allowing the droplets to overcome surface tension and escape. We know that the "cavitation effect" generates high temperature and high pressure, and its impact is inevitable, which is why ultrasonic atomizers cannot dry burn.

The working principle of the atomization device we are currently using is to use an ultrasonic diaphragm as a pump, which vibrates and sprays the liquid on one side of the diaphragm through horn shaped micropores from the other side. The size of the micropores determines the fineness of the droplets. During the spraying process, the liquid carries away the heat generated by vibration, so it does not produce high temperature and high pressure (can operate without water), thus overcoming the defects of the original ultrasonic atomization. We fully utilized the advantage of this device and developed a small animal nebulization drug delivery device

(1) Fine atomized particles (lt; 3um) can smoothly enter the alveoli.

(2) Real time standard calibration of atomization volume can be performed after using different liquids or replacing atomization heads.

(3) Can use different volumes of containers or administer nasal inhalation to individually housed animals.

(4) Can conveniently add medication, clean, replace animal containers, and atomizer heads.

(5) There is a filtering exhaust system and manual counting of cough sounds, as well as cough sound time recording (latent period) function.