Thermo Fisher mass spectrometer Orbitrap Astral Zoom

Orbitrap Astral ZoomUltra high resolution mass spectrometry system

Orbitrap Astral ZoomReshaping the latest peak of mass spectrometry technology. With its resolution, sensitivity, and high throughput,Astral ZoomNot only can it meet current scientific research needs, but it also provides unlimited possibilities for future scientific exploration.

Thermo Fisher mass spectrometer Orbitrap Astral ZoomFeatures:

• Higher throughput: analyzable in a single day300Sample size, reshape large queue research flux

upgradedAstralThe quality analyzer can achieve up to270 HzThe scanning speed Combined withVanquish Neo UHPLCsystem andEASY Spray PepMapChromatographic column, to4.8Minute gradient, from200 ng HelaMore than was identified in the cell protease digestion standard sample8,200A proteome.

• Deeper coverage: Pre enrichment function improves sensitivity and protein coverage depth, aiding in further research in systems biology

Combining high-speed ion filters with curved traps to achieve ion pre enrichment and enhance dynamic range(eDR)Mode, single injection can determine ultra precision10,000A proteome and200,000A unique peptide segment that supports more comprehensive protein sequence coverage and pathway annotation.

• Higher sensitivity: low input mode andTMT HRPattern enhancement enhances the ability to analyze trace samples and promotes high-throughput single-cell multi omics research

In low input mode, performLFQ DIAWhen collecting, it is possible to250 pgIdentified in the protease cleavage products of HeLa cells6,500Multiple proteins, or fromHEK293FAverage identification in single cells5,800Multiple types of proteins. passTMT proMultiple detection of reagents to achieve single day analysis exceeding2,000The high-throughput of single-cell proteomics further improves the efficiency of single-cell proteomics research.

• More possibilities: high quantitative dynamic range, simultaneous quantification of high abundance and low abundance proteins with high quantitative accuracy and precision; Enhance the energy of step collision and improve the performance of mass spectrometry in cutting and cross-linking detection, thereby providing new information in structural biology; Higher sensitivity helps spatial genomics achieve deep coverage of proteins and metabolites, providing a more comprehensive understanding of the molecular basis of cellular tissues, signaling networks, and diseases.

Thermo Fisher mass spectrometer Orbitrap Astral ZoomApplication Scenario:

• Proteomics: high-throughput single-cell proteomics, targeted pathway biology, immunopeptidomics

• Metabolomics: Single cell metabolomicsSQUADAnalysis, lipidomics

• Clinical research: clinical cohort studies, microbial host interactions, oncology applications